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	Esmaiel Jabbari Phone 803.777.8022 Fax 803.777.8265 E-mail 2C11 Swearingen Chemical Engineering University of South Carolina 301 Main St. Columbia, SC 29208 Curriculum Vitae Research Group Open Positions Resources		Esmaiel Jabbari Associate Professor Jabbari’s group research interests are in the areas of tissue engineering, biomaterials, and drug delivery. Tissue regeneration and maintenance is a complex process involving the interactions of cells with growth and differentiation factors, cytokines, and extracellular components. These guiding signals originate from the interactions of cells with bioactive peptide domains attached to the collagenous network or the non-collagenous soluble factors of the extracellular matrix. Continued progress in tissue engineering depends on our ability to develop novel materials and peptide/protein delivery systems that can mimic the signaling factors involved in the regeneration cascade of chemotaxis, cell migration, matrix degradation, cell homing, extracellular matrix formation and remodeling. These structures seeded with pluripotent stem cells allow us to elucidate the fundamental relationship between the material structure and cell morphogenesis and expression. Such understanding is critical for the development of tissue-engineered constructs to treat a variety of diseases including musculoskeletal, cardiovascular, and neural disorders. Active projects in Jabbari’s group include biologically inspired nanocomposites for bone regeneration, targeted tumor delivery with peptidomimetic self-assembled nanoparticles, stem cells morphogenesis on biomimetic substrates, and fabrication of bioresorbable scaffolds with well-defined pore geometry by rapid-prototyping. Education Ph. D. Chemical Engineering, Purdue University (1993) Selected Publications "Targeted delivery with peptidomimetic conjugated self-assembled nanoparticles", Jabbari E, Pharmaceutical Research, in press (2008). "Effect of grafting RGD and BMP-2 protein-derived peptides to a hydrogel substrate on osteogenic differentiation of marrow stromal cells", He X, Ma J, Jabbari E, Langmuir, 24(21):12508-12516 (2008). "Release characteristics of a model protein from self-assembled succinimide-terminated poly(lactide-co-glycolide ethylene oxide fumarate) nanoparticles", Mercado AE, He X, Xu W, Jabbari E, Nanotechnology, in press (2008). "Tissue specific shRNA delivery: A novel approach for gene therapy in cancer", Ghatak S, Hascall VC, Berger FG, Pena MM, David C, Jabbari E, He X, Dang Y, Markwald RR, Misra S. Connective Tissue Research, 49(3):265-269 (2008). "Modeling kinetics of cell adhesion on substrates with ligand density gradient", Sarvestani AS, Jabbari E, Journal of Biomechanics, 41(4):921-925 (2008). "Cytotoxicity of paclitaxel in biodegradable self-assembled core-shell poly(lactide-co-glycolide ethylene oxide fumarate) nanoparticles", He X, Ma J, Mercado AE, Xu W, Jabbari E Pharmaceutical Research, 25(7):1552-1562 (2008). "Concurrent differentiation of marrow stromal cells to osteogenic and vasculogenic lineages", Henderson JA, He X, Jabbari E, Macromolecular Biosciences, 8:499-507 (2008). "Material properties and bone marrow stromal cells response to in situ crosslinkable rgd-functionlized lactide-co-glycolide scaffolds", Jabbari E, He X, Valarmathi MT, Sarvestani AS, Xu W, Journal of Biomedical Materials Research, in press (2008)

Swearingen Engineering Center | Columbia, SC 29208 | 803.777.4181 | www-che@engr.sc.edu

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