Professor Papathanasiou's interests center in the investigation of processing-structure-property relationships in composite materials and other multiphase systems. Our approach uses high performance computing on realistic meso-scale structures to investigate the influence of topology on the details of the stress, thermal, electrical and flow fields in such systems. These influences are a critical step in developing a better and quantitative understanding of the effect of structure on the performance of composite materials. Our simulations are carried out on geometries determined from real composite materials using large-area automated microscopy. One group of projects involves the use of the boundary element method, implemented on parallel distributed memory computers, to directly relate the elastic deformation of composites to their detailed structure. Quantification of the latter from digital micrographs is also of interest. Another project deals with the computational determination of flow patterns in the case of fluid flow through Structured Fibrous Porous Media (SFPM). Both Stokes- and finite-Reynolds-number flows are considered; the objective is to develop quantitative models for the effective permeability of SFPM as function of meso-structural parameters. In the area of processing we are interested in establishing how the meso-structure of a particle- or fiber-reinforced melt is affected by processing, particularly by the flows occurring during filling of cold cavities. Other projects of interest include environmentally conscious manufacturing of composite materials, injection molding of polymers and composites and transport phenomena in bioreactors and living systems.